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DOI: 10.5146/tjpath.2014.01259
A Translocation Renal Cell Carcinoma with Skeletal Muscle Metastasis in a Child
Gülen TÜYSÜZ1, Nihal ÖZDEMİR1, Haluk EMİR2, Haydar DURAK3, Sergülen DERVİŞOĞLU3, İbrahim ADALETLİ4, Hilmi APAK1
1Departments of Pediatric Hematology Oncology, İstanbul University, Cerrahpaşa Medical Faculty, İSTANBUL, TURKEY
2Departments of Pediatric Surgery, İstanbul University, Cerrahpaşa Medical Faculty, İSTANBUL, TURKEY
3Departments of Pathology, İstanbul University, Cerrahpaşa Medical Faculty, İSTANBUL, TURKEY
4Departments of Radiology, İstanbul University, Cerrahpaşa Medical Faculty, İSTANBUL, TURKEY
Keywords: Translocation renal cell carcinoma, Pediatric, Skeletal muscle, Metastases

Renal cell carcinoma is a tumor that is well known for a high rate of metastasis to several locations like the lung, liver and bones. Skeletal muscle is a rare location for dissemination of the disease. Herein, we describe a 7-year-old boy who presented with flank pain. On physical examination, an abdominal mass located on the left kidney as well as a solid palpable lesion on the left upper arm were detected. Total nephrectomy with subsequent excision of the arm mass was performed. Pathology examination revealed presence of translocation renal cell carcinoma. The patient received α-interferon followed by multikinase inhibitor (Sorafenib) treatment but was lost due to progressive disease. This is the first description of a pediatric patient with skeletal muscle metastases of translocation renal cell carcinoma in the literature.

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