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DOI: 10.5146/tjpath.2018.01424
Evaluation of p53 and Ki67 Expression Profiles in Basal Cell Carcinomas in a Usual and an Unusual Location
Nuran SÜNGÜ1, Merve Meryem KIRAN1, Hayriye TATLI DOĞAN1, Aydan KILIÇARSLAN1, Emre KARAKÖK1, Mesut AKYOL2
1Department of Pathology, Ankara Yıldırım Beyazit University, Ankara Ataturk Research and Training Hospital, ANKARA, TURKEY
2Department of Biostatistics, Ankara Yıldırım Beyazit University, Ankara Ataturk Research and Training Hospital, ANKARA, TURKEY
Keywords: Basal cell carcinoma, p53, Ki67, Location

Objective: Owing to their importance in cell proliferation in cutaneous malignancies, we aimed to immunohistochemically compare the expression profiles of p53 and Ki67 in basal cell carcinoma (BCC) cases in both a usual and an unusual locations in this study.

Material and Method: In this study we included 12 in an unusual location of BCC cases and 21 BCC cases in a usual location. Immunohistochemical expression of p53 and Ki67 antibodies were studied in 33 paraffin-embedded tissue specimens of basal cell carcinoma. We compared the p53 and Ki67 staining scores with clinicopathologic features.

Results: The tumor size was found to be greater in BCC cases in an unusual location than those in a usual location. The relationship between age and tumor size was also evaluated in both groups and it was found that tumor size increased with age. A comparative study between the two groups showed no difference p53 and Ki67 expression percentages. There was a linear correlation between the Ki67 and p53 marker staining rates (ρ=0.420; p=0.015). In the samples taken from cases in a usual region, there was a linear and moderate relationship between the markers (ρ=0.513; p=0.017). Median tumor diameter results were similar to the marker staining score (p>0.05).

Conclusion: This is the first study comparing the expression profiles of p53 and Ki67 of BCC cases in an unusual and a usual location. No significant difference was found concerning Ki67 and p53 expression levels between the two groups.

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