Home About the Journal Editors International Editorial Board Instructions for Authors Abstracting&Indexing E-pub Ahead Of Print Contact This journal is a member of, and subscribes to the principles of, the Committee on Publication Ethics (COPE) Table of Contents [ PDF ] [ Similar Articles ] DOI: 10.5146/tjpath.2020.01511 Tall Cell Carcinoma with Reverse Polarity of Breast: Report of a Case with Unique Morphologic and Molecular Features Mohamed JASSIM1, Chennagiri S PREMALATA1, Geeta V Patil OKALY1, Chunduri SRINIVAS2 1Department of Pathology, Kidwai Memorial Institute of Oncology, Bengaluru, INDIA 2Department of Surgical Oncology, Kidwai Memorial Institute of Oncology, Bengaluru, INDIA Keywords: Breast carcinoma, Tall cell carcinoma, Reverse polarity, Solid papillary, IDH2 Breast carcinomas are a heterogeneous group of malignancy, having variable clinical outcomes depending on their cellular and molecular properties. Tall cell carcinoma with reverse polarity (TCCRP) is a recently described rare entity, which shares morphological features with tall cell variant of papillary thyroid carcinoma but has a distinct morphological, immunohistochemical, and molecular profile. We describe a case of a 40-year-old female patient, who presented with lump in the breast. The patient underwent lumpectomy and was diagnosed as tall cell carcinoma with reverse polarity. Immunohistochemistry and bi-directional Sanger sequencing for IDH2 mutation were used for diagnosis. Tall cell carcinoma with reverse polarity is a rare and newly described entity with characteristic morphological and molecular findings, which carries an excellent prognosis. [ PDF ] [ Similar Articles ]