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DOI: 10.5146/tjpath.2021.01528
Evaluation of the mir-126, mir-182, and mir-486-5p Expression Signature of Head and Neck Squamous Cell Carcinomas and Lung Squamous Cell Carcinomas
Gizem ISSIN1, Zafer KUCUKODACI2, Ismail YILMAZ2, Evren ERKUL3, Ersin TURAL4, Dilaver DEMIREL5, Atila GUNGOR6, Sukru YILDIRIM7
1Department of Pathology, Erzincan Binali Yildirim University, Mengucek Gazi Training and Research Hospital, ERZINCAN, TURKEY
2University of Health Sciences, İstanbul Sultan 2. Abdülhamid Han Training Hospital, ISTANBUL, TURKEY
3Department of Otorhinolaryngology, Gulhane Medical School, University of Health Sciences, İstanbul Sultan 2. Abdülhamid Han Training Hospital, ISTANBUL, TURKEY
4Department of Pediatrics, University of Health Sciences, İstanbul Sultan 2. Abdülhamid Han Training Hospital, ISTANBUL, TURKEY
5Department of Pathology, University of Health Sciences, Gaziosmanpasa-Taksim Health Application and Research Center, ISTANBUL, TURKEY
6Department of Otorhinolaryngology, Medical Park Goztepe Hospital, ISTANBUL, TURKEY
7Department of Pathology, Maltepe University, Faculty of Medicine, ISTANBUL, TURKEY
Keywords: Head and neck, Lung, Squamous cell carcinoma, mir-126, mir-182, mir-486-5p

Objective: Although squamous cell carcinomas (SCCs) originating from different anatomic localizations display a similar histological appearance under light microscopy, they may differ in terms of epigenetic and genetic features. The aim of this study was to analyze mir-126, mir-182, and mir-486-5p expression levels in head and neck SCCs and lung SCCs, and to identify localization-specific miRNA expression profiles.

Material and Method: The expression levels of mir-126, mir-182, and mir-486-5p were analyzed in lung, oral cavity, laryngeal, and hypopharyngeal SCCs in 40 patients, using quantitative real-time polymerase chain reaction.

Results: The findings showed that lung, oral cavity, laryngeal, and hypopharyngeal SCCs have distinct mir-126 and mir-486-5p expression profiles. It was also observed that mir-126 and mir-486-5p expression levels were highly specific to the tumor localization.

Conclusion: These findings highlighted that SCCs originating from different anatomic localizations have different miRNA expression profiles. miRNA expression analysis can be used to predict the primary localizations of those SCCs.


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