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2005, Volume 21, Number 3-4, Page(s) 049-053     
[ Abstract (Turkish) ] [ PDF ] [ Similar Articles ]
ASSOCIATION OF MACROPHAGES, EOSINOPHIL LEUKOCYTES AND NK CELLS WITH ANGIOGENESIS AND DEPTH OF INVASION IN COLORECTAL CARCINOMAS
Dr. Canten Tataroğlu1, Dr. Ayşe Polat2, Dr. Aydanur Kargı3, Dr. Selma Şengiz4, Dr. Handan Çamdeviren5, Dr. Ali Küpelioğlu3
1Denizli Devlet Hastanesi Patoloji Bölümü, Denizli
2Mersin Üniversitesi Tıp Fakültesi Patoloji Anabilim Dalı, Mersin
3Dokuz Eylül Üniversitesi Tıp Fakültesi Pataloji Anabilim Dalı, İzmir
4M. Kazım Dinç Kandıra Devlet Hastanesi Patoloji Bölümü, Kocaeli
5Mersin Üniversitesi Tıp Fakültesi Biyoistatik Anabilim Dalı, Mersin
Keywords: Colorectal carcinoma, angiogenesis, macrophages, eosinophil leucocytes, natural killer cells (NK cells)

Colorectal carcinoma is one of the most frequently observed malignancy in the developed countries. Angiogenesis is essential for tumor growth and metastasis. The associations between peritumoral inflammatory cells and natural killer cells and angiogenesis to depth of invasion and lymph node metastasis were investigated in 75 colorectal adenocarcinoma specimens. There was not any statistically significant correlation between depth of invasion, lymph node metastasis and microvessel density, peritumoral macrophages, eosinophil leucocytes and naturel killer cells. There was a positive correlation between angiogenesis and peritumoral macrophages (p=0.021). Also natural killer cells and eosinophil leucocytes have a positive correlation (p=0.027). The relation between angiogenesis and eosinophil leucocytes and NK cells was insignificant. These data indicate that peritumoral inflammatory cells may contribute to tumor angiogenesis, and the sinergistic effect between peritumoral inflammatory cells.

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