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2005, Volume 21, Number 3-4, Page(s) 054-057     
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PSEUDOANGIOMATOUS STROMAL HYPERPLASIA OF THE BREAST (MORPHOLOGICAL AND IMMUNOHISTOCHEMICAL ANALYSIS OF 14 CASES)
Sanem ÖZTÜRK1, Ekrem YAVUZ1, Memduh DURSUN2, Oktar ASOĞLU3, Rıdvan İLHAN1, Sıtkı TUZLALI1, Altan İPLİKÇİ1
1İstanbul Üniversitesi, İstanbul Tıp Fakültesi, Patoloji Anabilim Dalı, İstanbul
2İstanbul Üniversitesi, İstanbul Tıp Fakültesi, Radyodiagnostik Anabilim Dalı, İstanbul
3İstanbul Üniversitesi, İstanbul Tıp Fakültesi, Genel Cerrahi Anabilim Dalı, İstanbul
Keywords: Breast, pseudoangiomatous stromal hyperplasia, CD34, progesterone receptor

Pseudoangiomatous stromal hyperplasia (PASH) is an uncommon, benign mesenchymal lesion of the breast. Histologically, it is characterized by complex, anastomosing, empty, slit-like spaces that are lined by spindle cells in a dense collagenous stroma. We have evaluated 14 PASH cases morphologically and immunohistochemically, using antibodies against CD34 and progesterone receptor and reviewed the relevant literature. Also, we have evaluated the mast cell population of the lesions, using Giemsa stain. All of the cases were women presenting with a mass in the breast. The diameter of the lesions ranged from 1 cm to 13,5 cm (mean diameter 4 cm). The spindle cells, lining the slit-like spaces, were immunoreactive for anti CD34 whereas all were negative for anti progesterone receptor. The mean mast cell count was 17,5/10 HPF. Although differential diagnosis of PASH includes several mesenchymal lesions appropriate macroscopic sampling and immunohistochemistry are usually sufficient for proper diagnosis. Nevertheless, detection of immunostaining for CD34, using immunohistochemistry, may support the morphologic diagnosis.

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