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2006, Volume 22, Number 1, Page(s) 005-010     
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Invasive breast carcinoma cases showing both estrogen and progesterone receptor positivity and c-erb B2 overexpression (a clinicopathologic study of 66 cases)
Ali BAli BAŞ1, Ekrem YAVUZ1, Sıtkı TUZLALI1, Rıdvan İLHAN1, Oktar ASOĞLU2, Neşe GÜNEY3
1İstanbul Üniversitesi, İstanbul Tıp Fakültesi Patoloji Anabilim Dalı, İstanbul
2İstanbul Üniversitesi, İstanbul Tıp Fakültesi Genel Cerrahi Anabilim Dalı, İstanbul
3İstanbul Üniversitesi Onkoloji Enstitüsü, İstanbul
Keywords: Invasive breast carcinoma, hormone receptor, c-erb B2, immunohistochemistry

We analyzed clinicopathologic characteristics of invasive breast carcinomas, where both hormone receptor positivity and c-erb B2 overexpression were detected by immunohistochemical methods. The rate of hormone receptor positivity for invasive breast carcinomas with c-erb B2 overexpression was 27.61% (66/239). The majority of the cases showed high levels of immunopositivity for hormone receptors. The mean age of patients was 52.96 while pre and postmenopausal patients were equal in number. The vast majority of the cases were high grade-invasive ductal carcinomas of low stages. Of 36 cases with available clinical follow-up, 8 displayed either local recurrence or distant metastasis in a relatively short duration (1-17 months). Our findings reveal that invasive breast carcinomas with both hormone receptor positivity and overexpression of c-erb B2 have a tendency to occur in premenopausal patients and have adverse prognostic characteristics even at low stages.

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