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2011, Volume 27, Number 1, Page(s) 023-030     
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DOI: 10.5146/tjpath.2010.01042
Profile of Gallbladder Diseases Diagnosed at Afyon Kocatepe University: A Retrospective Study
Mustafa MAZLUM1, Fatma Hüsniye DİLEK1, Arzu Neşe YENER2, Çiğdem TOKYOL1, Fatma AKTEPE1, Osman Nuri DİLEK3
1Department of Pathology, Afyon Kocatepe University, Faculty of Medicine, AFYONKARAHİSAR, TURKEY
2Department of Pathology, Maltepe University, Faculty of Medicine, İSTANBUL, TURKEY
3Department of General Surgery, Sakarya University, Faculty of Medicine, SAKARYA, TURKEY
Keywords: Cholelithiasis, Gallbladder diseases, Precancerous conditions, Gallbladder neoplasms, Cholecystectomy

Objective: Gallbladder is one of the most commonly encountered specimen in a pathology laboratory. A diverse spectrum of diseases affect the biliary system, often presenting with similar clinical signs and symptoms. We aimed to define the profile of gallbladder diseases in our region, and to determine potential correlations between histopathologic features we observed.

Material and Method: We reviewed all cholecystectomies processed in Department of Pathology of Afyon Kocatepe University Hospital between January 2000 and March 2008. Gross and histopathologic features of the specimens were reevaluated.

Results: Among 1500 patients; 69.9% were women and 30.1% were men. We found out fourteen primary gallbladder carcinomas (0.93%) with adenocarcinomas being the most frequent type (78.57%). The rate of cholelithiasis was found as 89.9%. The most common type of gallstones was mixed cholesterol type gallstones with 67.5% followed by black pigment and brown pigment types as 23.83% and 5.89%, respectively. The association of metaplasia with dysplasia and also gallstones were statistically significant (p<0.001, p<0.005). The rate of the gallbladder polyps was 2.6% with the cholesterol polyps being the most common type (56.4%).

Conclusion: Gallbladder diseases often present with similar clinical signs and symptoms and a surgical pathologist should be alert especially of precancerous lesions. With our results, we also conclude that elderly women with longstanding gallstone disease should undergo elective surgery even when no symptoms are present.


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