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2012, Volume 28, Number 1, Page(s) 090-094     
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DOI: 10.5146/tjpath.2012.01106
Carcinosarcoma of the Lung Associated with Neurofibromatosis Type 1: A Case Report
Rana ÇİTİL1, Harun ÇIRALIK2, Ahmet KARSLIGİL3, Pembe OLTULU1, Derya YENİBERTİZ4, Hamide Sayar2, Esma Gürbüz2
1Department of Pathology, Kahramanmaraş State Hospital, KAHRAMANMARAŞ, TURKEY
2Department of Pathology, Sütçü İmam University, Faculty of Medicine, KAHRAMANMARAŞ, TURKEY
3Department of Thoracic Surgery, Kahramanmaraş State Hospital, KAHRAMANMARAŞ, TURKEY
4Department of Chest Diseases, Kahramanmaraş State Hospital, KAHRAMANMARAŞ, TURKEY
Keywords: Neurofibromatosis 1, Carcinosarcoma, Lung

Neurofibromatosis or von Recklinghausen's disease is the most common inherited syndrome predisposing to neoplasia. Carcinosarcoma is a rare malignant mixed tumor of the lung. Association of carcinosarcoma of lung with Neurofibromatosis-1 is not common. A 57-year-old man presented with history of fever, cough, hemoptysis, breathlessness, weight loss, chest pain. Multiple cutaneous neurofibromas and café au lait spots were revealed by physical examination. A homogeneous opacity was found in the right middle and right upper zone on posterior-anterior chest radiography. A 8x8x7 cm mass that had irregular borders in right upper posterior and apical segment was seen on contrast enhanced chest computed tomography. On bronchoscopy, the lumen of right upper apical segment was obstructed with vegetating tumoral lesion. The biopsy taken from this region was diagnosed as carcinosarcoma by histopathological and immunohistochemical examination.A rare case with carcinosarcoma of the lung and Neurofibromatosis-1 was reported.

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