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2012, Volume 28, Number 2, Page(s) 104-109     
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DOI: 10.5146/tjpath.2012.01108
Association Between the Proportion of Sclerotic Glomeruli and Serum Creatinine in Primary Focal Segmental Glomerulosclerosis
Ashraf FAKHRJOU, Ahad HASHEMPOUR, Sepideh SHADRAVAN, Rohollah Fadaei FOULADI
Department of Pathology, Tabriz University of Medical Sciences, Imam Reza Hospital, TABRIZ, IRAN
Keywords: Focal-segmental glomerulosclerosis, Creatinine, Creatinine metabolic clearance rate, Histopathology

Objective: To evaluate the possible correlation between the extent of sclerotic glomeruli and the level of serum creatinine and its clearance rate in patients with primary focal segmental glomerolusclerosis.

Material and Method: In a cross-sectional study, 50 patients with biopsy-proven primary focal segmental glomerolusclerosis were recruited. The proportion of globally and segmentally sclerosed glomeruli was determined during the first histopathological examination of renal biopsy specimens. Correlations of these variables with on admission serum level of creatinine and its clearance rate were investigated.

Results: Twenty-four males and 26 females with a mean age of 39.8216.45 (range: 16-85) years were enrolled in the study. In a significant fashion, the proportions of segmental and global glomerulosclerosis were directly correlated with the serum level of creatinine and inversely with its clearance rate (r=-0.43 with p=0.002 and r=-0.45 with p=0.001, respectively).

Conclusion: Apart from the degree of interstitial fibrosis, the serum level of creatinine and its clearance rate are well correlated with the proportions of both segmentally and globally sclerosed glomeruli in primary focal segmental glomerulosclerosis.


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