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2012, Volume 28, Number 3, Page(s) 286-289     
[ Abstract (Turkish) ] [ PDF ] [ Similar Articles ]
DOI: 10.5146/tjpath.2012.01139
Primary Lymphoepithelioma-Like Carcinoma of the Lung: Report of a Rare Case and Review of the Literature
Neşe Arzu YENER1, Ahmet BALIKÇI2, Rahmi ÇUBUK3, Ahmet MİDİ1, Alpay ÖRKİ4, Aynur EREN TOPKAYA2
1Department of Pathology, Maltepe University, Faculty of Medicine, İSTANBUL, TURKEY
2Department of Microbiology, Maltepe University, Faculty of Medicine, İSTANBUL, TURKEY
3Department of Radiology, Maltepe University, Faculty of Medicine, İSTANBUL, TURKEY
4Department of Chest Surgery, Maltepe University, Faculty of Medicine, İSTANBUL, TURKEY
Keywords: Epstein-Barr virus, Carcinoma, Lymphoepitheliomalike, Lung cancer

Primary lymphoepithelioma-like carcinoma of the lung is a rare type of non-small cell lung carcinoma. In this study, we aimed to present a 62-year-old smoker male with a primary lymphoepithelioma-like carcinoma of the hilar region of the left lung. The patient underwent left pneumonectomy and no adjuvant therapy was given. There were no other abnormalities on whole body PET/CT scan including the nasopharyngeal region. The patient showed seropositivity for EBV IgG but immunohistochemistry and PCR amplification studied on paraffin-embedded tissue sections of the tumor failed to show any sign of EBV infection within the tumor cells. He is alive and disease-free four months after the operation. Although primary lymphoepithelioma-like carcinoma of the lung is usually reported in young females with no history of tobacco use and the tumor cells are infected with EBV, it may rarely be seen in elderly males with a history of tobacco use and the tumor cells not infected with EBV.

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