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2012, Volume 28, Number 3, Page(s) 286-289
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DOI: 10.5146/tjpath.2012.01139 |
Primary Lymphoepithelioma-Like Carcinoma of the Lung: Report of a Rare Case and Review of the Literature |
Neşe Arzu YENER1, Ahmet BALIKÇI2, Rahmi ÇUBUK3, Ahmet MİDİ1, Alpay ÖRKİ4, Aynur EREN TOPKAYA2 |
1Department of Pathology, Maltepe University, Faculty of Medicine, İSTANBUL, TURKEY
2Department of Microbiology, Maltepe University, Faculty of Medicine, İSTANBUL, TURKEY
3Department of Radiology, Maltepe University, Faculty of Medicine, İSTANBUL, TURKEY
4Department of Chest Surgery, Maltepe University, Faculty of Medicine, İSTANBUL, TURKEY |
Keywords:
Epstein-Barr virus, Carcinoma, Lymphoepitheliomalike, Lung cancer |
Primary lymphoepithelioma-like carcinoma of the lung is a rare type
of non-small cell lung carcinoma. In this study, we aimed to present
a 62-year-old smoker male with a primary lymphoepithelioma-like
carcinoma of the hilar region of the left lung. The patient underwent
left pneumonectomy and no adjuvant therapy was given. There were
no other abnormalities on whole body PET/CT scan including the
nasopharyngeal region. The patient showed seropositivity for EBV
IgG but immunohistochemistry and PCR amplification studied
on paraffin-embedded tissue sections of the tumor failed to show
any sign of EBV infection within the tumor cells. He is alive and
disease-free four months after the operation. Although primary
lymphoepithelioma-like carcinoma of the lung is usually reported
in young females with no history of tobacco use and the tumor cells
are infected with EBV, it may rarely be seen in elderly males with a
history of tobacco use and the tumor cells not infected with EBV.
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