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2017, Volume 33, Number 2, Page(s) 168-170     
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DOI: 10.5146/tjpath.2014.01290
Malignant Melanoma Presenting as a Mediastinal Malignant Melanoma Presenting as a Mediastinal Unknown Primary Origin?
Mukta PUJANI1, Mohd Jaseem HASSAN1, Sujata JETLEY1, Prabhat Kumar RAINA2, Mukesh KUMAR3
1Department of Pathology, Hamdard Institute of Medical Sciences & Research, NEW DELHI, INDIA
2Department of Surgery, Hamdard Institute of Medical Sciences & Research, NEW DELHI, INDIA
3Department of Radiology, Hamdard Institute of Medical Sciences & Research, NEW DELHI, INDIA
Keywords: Malignant melanoma, Neoplasm of unknown primary, Mediastinal neoplasm

The most common site of primary malignant melanoma is the skin, however, virtually any organ system may be involved. Metastatic melanoma of unknown primary origin accounts for approximately 2-6% of all melanoma cases. The mediastinum as the site for malignant melanoma is extremely rare, both as a primary or metastatic lesion. Primary malignant melanoma of mediastinum is very rare with only a handful of reports in the literature. We hereby report a rare case of malignant melanoma of mediastinum in a 31 year old male who was initially misdiagnosed on fine needle aspiration cytology as adenocarcinoma for which he received chemotherapy with clinical deterioration. Even on extensive meticulous search, no primary was discovered.

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