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2018, Volume 34, Number 1, Page(s) 100-103
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DOI: 10.5146/tjpath.2015.01301 |
We can Diagnose it if we Consider it. Diagnostic Pitfall for Placenta: Placental Mesenchymal Dysplasia |
Havva Serap TORU1, Esra ÇOBANKENT AYTEKİN1, Cem Yaşar SANHAL2, Sezin YAKUT3, Zafer ÇETİN4, İbrahim İnanç MENDİLCİOĞLU2, Hadice Elif PEŞTERELİ1 |
1Department of Pathology, Akdeniz University, School of Medicine, ANTALYA, TURKEY 2Department of Obstetrics and Gynecology, Akdeniz University, School of Medicine, ANTALYA, TURKEY 3Department of Medical Biology and Genetics, Akdeniz University, School of Medicine, ANTALYA, TURKEY 4Department of Medical Biology, SANKO University School of Medicine, GAZİANTEP, TURKEY |
Keywords:
Placental mesenchymal dysplasia, Molar pregnancy, Diagnostic errors |
Placental mesenchymal dysplasia is an increasingly recognizable
abnormality. Early cases have been confused with partial hydatidiform
mole. Placental mesenchymal dysplasia is probably under-diagnosed
because of being an unfamiliar clinical entity and also mistaken for
gestational trophoblastic disease due to the similar sonographic
findings of two entities. In this report, we describe the clinical, gross,
and histopathological findings of placental mesenchymal dysplasia
in two cases. The 33-week-preterm baby of a 26-year-old woman
with cardiovascular disease and 342 gram placenta and the 19-week
fetus with trisomy 21 of a 40 year-old woman were terminated.
Macroscopically thick-walled vessels and microscopically hydropic
villous with peripherally localized thick-walled vessels without
trophoblastic cell proliferation were observed in both cases. These
two cases represent a rare placental anomaly that is benign but it is
challenging to distinguish placental mesenchymal dysplasia from
an incomplete mole. Placental mesenchymal dysplasia should be
included in the differential diagnosis of sonographic findings that
show a normal appearing fetus and a placenta with cystic lesions.
Placental mesenchymal dysplasia is associated with pregnancy-related
hypertension. In conclusion, the most important point is “you can
diagnose it if you consider it”.
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