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2015, Volume 31, Number 0, Page(s) 155-171     
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DOI: 10.5146/tjpath.2015.01322
Syndromes that Link the Endocrine System and Genitourinary Tract
Yasemin Özlük, Işın Kılıçaslan
Department of Pathology, Istanbul Faculty of Medicine, Istanbul University, İstanbul, Turkey
Keywords: Urogenital system, Endocrine system, SDH, TMEM127, VHL

The endocrine system and genitourinary tract unite in various syndromes. Genitourinary malignancies may cause paraneoplastic endocrine syndromes by secreting hormonal substances. These entities include Cushing`s syndrome, hypercalcemia, hyperglycemia, polycythemia, hypertension, and inappropriate ADH or HCG production. The most important syndromic scenarios that links these two systems are hereditary renal cancer syndromes with specific genotype/phenotype correlation. There are also some very rare entities in which endocrine and genitourinary systems are involved such as Carney complex, congenital adrenal hyperplasia and Beckwith-Wiedemann syndrome. We will review all the syndromes regarding manifestations present in endocrine and genitourinary organs.

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