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2019, Volume 35, Number 1, Page(s) 022-027
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DOI: 10.5146/tjpath.2018.01435 |
Diagnostic Value of Glucose Transporter 1 (GLUT-1) Expression in Nested Variant of Urothelial Carcinoma |
Ceren BOYACI1, Kemal BEHZATOĞLU2 |
1Department of Pathology, 1Sultanbeyli State Hospital, ISTANBUL, TURKEY 2Acıbadem Health Group, Atakent Acıbadem Hospital, ISTANBUL, TURKEY |
Keywords:
GLUT-1, Nested, Urothelial carcinoma, Immunohistochemistry |
Objective: Nested variant is bland-looking but aggressive subtype of urothelial carcinoma (UC). Cases having significant muscle invasion do
not cause problems but small and superficial biopsies may be challenging due to morphological similarities between nested variant urothelial
carcinoma and benign urothelial lesions.
Material and Method: We studied Glucose transporter 1 (GLUT-1), which is an integral membrane protein providing glucose pass through
plasma membrane down its concentration gradient, to see if it is useful for the differential diagnosis. Twenty five cases of nested variant urothelial
carcinoma and a control group consisting of 12 cases of cystitis glandularis, cystitis cystica and 4 cases of inverted papilloma were stained with
GLUT-1 immunohistochemically. Membranous staining was scored on a scale of 0 to +3.
Results: Eleven of 25 nested variant UC cases showed a score of 2 and 14 of them showed a score of 3 on immunostaining with GLUT-1. Two
cases showed a score of 1 and 10 cases did not show any staining in the control group.
Conclusion: Our results showed that GLUT-1 may be a helpful marker when morphological separation cannot be made between nested variant
UC and benign urothelial leisons. We also think that anti-GLUT-1 antibody treatment may be an option in the targeted treatment of nested
variant.
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