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2020, Volume 36, Number 3, Page(s) 251-255     
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DOI: 10.5146/tjpath.2019.01476
Uterine Leiomyoma with Massive Lymphoid Infiltrate in a Patient with History of Assisted In-Vitro Fertilization
Monia DI PRETE1, Matteo COLLAMARINI2, Claudio COLLAMARINI2, Francesco SESTI2, Alessandro MAURIELLO1, Giampiero PALMIERI1
1Department of Anatomic Pathology,University of Rome Tor Vergata, ROME, ITALY
2Department of Gynaecology and Obstetrics, University of Rome Tor Vergata, ROME, ITALY
Keywords: Leiomyoma, In-vitro fertilization, Uterine, Lymphoma

Uterine leiomyomas are the most common benign tumors of the gynecological tract. Massive lymphocytic infiltration has been reported rarely in uterine leiomyomas and it has been described as a pathogenetic correlation with gonadotropin-releasing hormone agonists. Uterine leiomyomas with massive lymphoid infiltration have to be differentiated from non-Hodgkin lymphomas. We report a case of a woman without a history of gonadotropin-releasing hormone agonist treatment, who presented with a uterine leiomyoma that increased in size after the procedure of assisted in-vitro fertilization, and associated with massive nodular lymphoid infiltrate simulating, morphologically, a non-Hodgkin lymphoma. Uterine leiomyoma with massive lymphocytic infiltration is a very rare entity, probably of reactive significance, which has to be differentiated from diseases that need a systemic therapeutic approach.

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