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2015, Volume 31, Supplement
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DOI: 10.5146/tjpath.2015.01320
An Update of Neuroendocrine Tumors of the Female Reproductive System
Mehmet Kefeli1, Alp Usubütün2
1Department of Pathology, Ondokuz Mayıs University Faculty of Medicine, Samsun, Turkey
2Hacettepe University Faculty of Medicine, Ankara, Turkey
Keywords: Neuroendocrine tumors, Female genital neoplasms, Paraganglioma, Neuroendocrine cells, Immunohistochemistry
Abstract
Endocrine disease related tumors of female reproductive system mostly seen in ovary. Hormone producing ovarian tumors, ovarian tumor with functioning stroma, tumor related paraneoplastic and paraendocrine syndromes, paraganglioma and neuroendocrine tumors may include in this category. These tumors or its stroma can produce some hormones, which are led to endocrine manifestations. Rarely tumors associated with paraneoplastic and endocrine syndromes. Among these lesions, primary neuroendocrine tumors are rarely seen in the gynecologic tract, comprising 2% of gynecologic cancers. They have specific cytological and histopathological features that are usually helpful in differentiating them from epithelial tumors. Nevertheless, they still provide a diagnostic and clinical challenge, given their rarity. Accurate diagnosis of neuroendocrine tumor is essential for both therapeutic and prognostic purposes. In this review, we focused on neuroendocrine tumors of the gynecological tract and their morphological, immunohistochemical and molecular findings. In addition, we will briefly discuss paraganglioma and other endocrine diseases related tumors in the gynecological tract.
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