Turkish Journal of Pathology

Türk Patoloji Dergisi

Turkish Journal of Pathology

Turkish Journal of Pathology

2005, Vol 21, Num, 3-4     (Pages: 062-066)

THE UTILITY OF HISTOMORPHOLOGICAL FEATURES IN THE DIFFERENTIATION OF EOSINOPHILIC CHROMOPHOBE RENAL CELL CARCINOMA AND ONCOCYTOMA

Özgür METE 1, Işın KILIÇASLAN 1, Veli UYSAL 1

1 İstanbul Üniversitesi, İstanbul Tıp Fakültesi Patoloji Anabilim Dalı, İstanbul

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Renal oncocytomas and eosinophilic variants of chromophobe renal cell carcinomas have similar histological and cytological features. In order to identify some histological parameters for differentiating these tumours, 51 renal oncocytomas and 32 chromophobe renal cell carcinoma were included in our study. Nuclear, cytoplasmic, structural and stromal features are investigated in both tumours. The presence of well-defined nuclear border, fibrohyalinised scar, stromal oedema and entrapped tubules are found to be significant (p<0,05) for oncocytomas. The presence of necrosis, perinuclear halo and special vascular network are found to be significant (p<0,05) in chromophobe renal cell carcinomas.

Keywords : Renal cell carcinoma, oncocytoma