Turkish Journal of Pathology

Türk Patoloji Dergisi

Turkish Journal of Pathology

Turkish Journal of Pathology

2011, Vol 27, Num, 3     (Pages: 221-229)

General Evaluation of Hepatectomy and Hepatocellular Carcinoma Cases

Nuray BAŞSÜLLÜ 1, İlknur TÜRKMEN 1, Onur YAPRAK 2, Murat DAYANGAÇ 2, Tolga DEMİRBAŞ 2, Necdet GÜLER 2, Süleyman URAZ 3, Murat AKYILDIZ 4, Engin CİĞERCİOĞULLARI 5, Yaman TOKAT 2, Yıldıray YÜZER 2, Gülen BÜLBÜL DOĞUSOY 1

1 Department of Pathology, İstanbul Bilim University, Faculty of Medicine, İSTANBUL, TURKEY
2 Department of General Surgery Organ Transplantation, Şişli Florence Nightingale Hospital, İSTANBUL, TURKEY
3 Department of Gastroenterology, Şişli Florence Nightingale Hospital, İSTANBUL, TURKEY
4 Department of Gastroenterology, İstanbul Bilim University, Faculty of Medicine, İSTANBUL, TURKEY
5 Department of Medical Pathology, Ağrı Maternity and Pediatric Hospital, AĞRI, TURKEY

DOI: 10.5146/tjpath.2011.01079
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Objective: Although the clinical and histopathological findings of hepatocellular carcinoma are well described, there are few national studies. In this study, we aimed to investigate the relationship between these findings in total or partial hepatectomy specimens in our series.

Material and Method: We first collected 190 cases of total or partial hepatectomies performed because of hepatocellular carcinoma, cirrhosis or other disorders from the archives of Pathology. After re-examining the histopathological and clinical features such as age, gender and etiology, the relationship between them and serology results were statistically analyzed using the chi square and Multiple Comparison Tests.

Results: Among 190 cases, there were 168 (88.5%) total and 18 (9.5%) partial hepatectomies and 4 (2%) tumorectomy or metastasectomy cases. After gross and microscopic examination, 170 (89.5%) cases had a diagnosis of cirrhosis, 85 (44.7%) hepatocellular carcinoma, 3 parasitic cyst, 7 metastasis, 1 hepatoblastoma, 1 hepatocellular adenoma, 2 cholangiocarcinoma, 2 Budd Chiari Syndrome, 1 focal nodular hyperplasia, 1 cavernous hemangioma, and 2 acute fulminant hepatitis.

Among the hepatocellular carcinoma cases, 53 had Hepatitis B virus, 15 Hepatitis C virus , 3 Hepatitis B virus and Hepatitis C virus, and 3 Hepatitis B virus and Hepatitis delta virus etiology, while 6 were alcoholic and 4 were due to other causes. Among cirrhosis patients, 84 (49.4%) had hepatocellular carcinoma. The male to female ratio of hepatocellular carcinoma cases was 74/11. The mean age was 55 and the median age 56.7.

Conclusion: The results of this study demonstrated that the most common hepatic disorder was cirrhosis due to Hepatitis B virus in the hepatectomy specimens of our series that mostly consisted of total hepatectomies performed for transplantation where 50% had hepatocellular carcinoma.

Keywords : Transplantation, Cirrhosis, Hepatocellular carcinoma, Etiology