Turkish Journal of Pathology

Türk Patoloji Dergisi

Turkish Journal of Pathology

Turkish Journal of Pathology

2012, Vol 28, Num, 1     (Pages: 090-094)

Carcinosarcoma of the Lung Associated with Neurofibromatosis Type 1: A Case Report

Rana ÇİTİL 1, Harun ÇIRALIK 2, Ahmet KARSLIGİL 3, Pembe OLTULU 1, Derya YENİBERTİZ 4, Hamide Sayar 2, Esma Gürbüz 2

1 Department of Pathology, Kahramanmaraş State Hospital, KAHRAMANMARAŞ, TURKEY
2 Department of Pathology, Sütçü İmam University, Faculty of Medicine, KAHRAMANMARAŞ, TURKEY
3 Department of Thoracic Surgery, Kahramanmaraş State Hospital, KAHRAMANMARAŞ, TURKEY
4 Department of Chest Diseases, Kahramanmaraş State Hospital, KAHRAMANMARAŞ, TURKEY

DOI: 10.5146/tjpath.2012.01106
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Neurofibromatosis or von Recklinghausen's disease is the most common inherited syndrome predisposing to neoplasia. Carcinosarcoma is a rare malignant mixed tumor of the lung. Association of carcinosarcoma of lung with Neurofibromatosis-1 is not common. A 57-year-old man presented with history of fever, cough, hemoptysis, breathlessness, weight loss, chest pain. Multiple cutaneous neurofibromas and café au lait spots were revealed by physical examination. A homogeneous opacity was found in the right middle and right upper zone on posterior-anterior chest radiography. A 8x8x7 cm mass that had irregular borders in right upper posterior and apical segment was seen on contrast enhanced chest computed tomography. On bronchoscopy, the lumen of right upper apical segment was obstructed with vegetating tumoral lesion. The biopsy taken from this region was diagnosed as carcinosarcoma by histopathological and immunohistochemical examination.A rare case with carcinosarcoma of the lung and Neurofibromatosis-1 was reported.

Keywords : Neurofibromatosis 1, Carcinosarcoma, Lung