Turkish Journal of Pathology

Türk Patoloji Dergisi

Turkish Journal of Pathology

Turkish Journal of Pathology

2006, Vol 22, Num, 3     (Pages: 148-152)

Nuclear morphometry associated with Gleason score in prostatic adenocarcinoma

Sibel BEKTAŞ 1, Banu DOĞAN GÜN 1, Burak BAHADIR 1, Aydın MUNGAN 2, Şükrü Oğuz ÖZDAMAR 1

1 Zonguldak Karaelmas Üniversitesi Tıp Fakültesi Patoloji, Anabilim Dalları, ZONGULDAK
2 Zonguldak Karaelmas Üniversitesi Tıp Fakültesi Üroloji Anabilim Dalları, ZONGULDAK

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Quantitative morphometric methods have been tried to develop objective grading system in prostatic adenocarcinoma. In this study morphometric analysis results of the prostatic adenocarcinoma were compared with the Gleason scores of 54 cases; 40 of them (74%) were prostate needle biopsy specimens and 14 (26%) were prostatectomy specimens. For each case, about 150 nuclei were included for the morphometric analysis. After transferring microscopic images to the computer, nuclear area, roundness factor, and form ellipse were automatically measured by an image analysis program. The relationship between Gleason score and these varieties were determined by using correlation analysis. Among all the specimens, Gleason score and mean nuclear areas showed significant moderate correlation (r:0.456, p=0.001). As the needle biopsy group concerned, strong correlation was determined between Gleason score and the mean nuclear area (r:0.752, p=0.001). As a result, in the prostatic adenocarcinoma, mean nuclear area assessment may support to evaluate pathologic status of the disease.

Keywords : Nuclear morphometry, Gleason score, adenocarcinoma, prostate