Splenic epidermoid cyst is a rare cystic disease of spleen. Primary cysts of the spleen lined by epithelium or endothelium are usually seen in young adults. A 23-year-old woman with abdominal distension presented at the surgery outpatients of our hospital. Splenomegaly was detected on physical examination and elective surgery was performed. The multiloculated cyst was 10x6 cm on macroscopic examination and creamy material was drained. Immunohistochemical examination of the cyst lined with epithelium was Cytokeratin and CEA positive and calretinin, BerEP4, HBME-1 and F8 negative and it was reported as ‘epidermoid cyst'. We discussed the etiopathogenesis of our case in light of the theories regarding its development.