Turkish Journal of Pathology

Türk Patoloji Dergisi

Turkish Journal of Pathology

Turkish Journal of Pathology

2013, Vol 29, Num, 3     (Pages: 210-216)

HPV Types in Turkey: Multicenter Hospital Based Evaluation of 6388 Patients in Turkish Gynecologic Oncology Group Centers

Polat DURSUN 1, Ali AYHAN 1, Levent MUTLU 1, Mete ÇAĞLAR 1, Ali HABERAL 1, Taygun GÜNGÖR 2, Mustafa ÖZAT 2, Emre ÖZGÜ 2, Anıl ONAN 3, Çağatay TAŞKIRAN 3, Haldun GÜNER 3, Hakan YETİMALAR 4, Burcu KASAP 4, Kunter YÜCE 5, M. Coşkun SALMAN 5, Berkan SAYAL 5, Selen DOĞAN 5, Müge HARMA 6, Mehmet HARMA 6, Mustafa BASARAN 6, Hüseyin AYDOĞMUŞ 7, Yusuf ERGÜN 7, Salim ŞEHİRALİ 8, Emre GÜLTEKİN 8, Şükran KÖSE 8, Yusuf YILDIRIM 8, Müfit YENEN 9, Murat DEDE 9, İbrahim ALANBAY 9, Rıza KARACA 9, Jale METİNDİR 10, Levent KESKİN 11, Işık ÜSTÜNER 11, Filiz AVŞAR 11, Hasan YÜKSEL 12, Selim KIRDAR 12

1 Department of Obstetrics and Gynecology, Başkent University, Faculty of Medicine, ANKARA, TURKEY
2 Zekai Tahir Burak Maternity Hospital, ANKARA, TURKEY,
3 Gazi University, Faculty of Medicine, ANKARA, TURKEY
4 Atatürk Education and Research Hospital, İZMİR, TURKEY
5 Hacettepe University, Faculty of Medicine, ANKARA, TURKEY
6 Karaelmas University, Faculty of Medicine, ZONGULDAK, TURKEY
7 Ankara Education and Research Hospital, ANKARA, TURKEY
8 Ege Maternity Hospital, İZMİR, TURKEY
9 Gülhane Military Medical Academy, ANKARA, TURKEY
10 Department of Gynecologic Oncology, Ankara Oncology Hospital, ANKARA, TURKEY
11 Atatürk Education and Research Hospital, ANKARA, TURKEY
12 Adnan Menderes University, Faculty of Medicine, AYDIN, TURKEY

DOI: 10.5146/tjpath.2013.01188
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Objective: To evaluate the prevalence of HPV DNA and cervical cytological abnormalities, to compare cervical cytology results and HPV DNA and to define HPV types distribution in a large series of Turkish women who have undergone HPV analysis in hospitals that are members of the Turkish Gynecological Oncology Group.

Material and Method: Between 2006 and 2010, a total of 6388 patients’ data was retrospectively evaluated at 12 healthcare centers in Turkey. Demographic characteristics, cervical cytology results, HPV status and types were compared.

Results: The mean age of the patients was 38.9±10.2. Overall, 25% of the women were found to be HPV positive. Presence of HPV-DNA among patients with abnormal and normal cytology was 52% and 27%, respectively. There was significant diff erence with respect to decades of life and HPV positivity (p < 0.05). HPV was positive in (within the HPV (+) patients) 37%, 9%, 27%, 20%, 22%, and 41% of the ASCUS, ASC-H, LSIL HSIL, glandular cell abnormalities, and SCC cases respectively The most common HPV types in our study were as follows; HPV 16 (32%), HPV 6 (17%), HPV 11 (9%), HPV 18 (8%), HPV 31 (6%), HPV 51 (5%), HPV 33 (3%).

Conclusion: In this hospital based retrospective analysis, HPV genotypes in Turkish women with normal and abnormal cytology are similar to those reported from western countries. Further population based prospective multicenter studies are necessary to determine non-hospital based HPV prevalence in Turkish women.

Keywords : Human papillomavirus DNA tests, Mass screening, Uterine cervical neoplasms, Vaginal smears, Turkey