Turkish Journal of Pathology

Türk Patoloji Dergisi

Turkish Journal of Pathology

Turkish Journal of Pathology

2014, Vol 30, Num, 1     (Pages: 055-065)

Prognostic Significance of Bcl-2, C-Myc, Survivin and Tumor Grade in Synovial Sarcoma

Derya DEMİR 1, Banu YAMAN 2, Yavuz ANACAK 3, Burçin KEÇECİ 4, Gülşen KANDİLOĞLU 2, Taner AKALIN 2

1 Department of Pathology, Manisa State Hospital, MANİSA, TURKEY
2 Departments of Pathology, Ege University, Faculty of Medicine, İZMİR, TURKEY
3 Departments of Radiation Oncology, Ege University, Faculty of Medicine, İZMİR, TURKEY
4 Departments of Orthopaedics and Traumatology, Ege University, Faculty of Medicine, İZMİR, TURKEY

DOI: 10.5146/tjpath.2013.01221
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Objective: We aimed to determine the prognostic value of bcl-2, c-myc and survivin in synovial sarcoma cases and to evaluate the relationship between the conventional morphological findings with prognosis.

Material and Method: In this study, we evaluated 81 synovial sarcoma cases referred to our tertiary tumor center during a period of 20 years. We applied bcl-2, c-myc and survivin immunohistochemically and investigated the relationship with prognosis for those 65 cases with follow-up. The relationship between the conventional morphological findings (mitosis, necrosis, grade) with prognosis was also investigated.

Results: Five-year disease free survival rate was 44% and ten-year progression free survival rate was 38%, reflecting the aggressive behavior of synovial sarcoma. Tumor grade (according to FNCLCC) was the most significant prognostic input in this study. We obtained a significant difference between grade II (40 cases) and grade III (24 cases) group regarding progression-free survival and overall survival (p<0.001 and p<0.001 respectively). Grade II was divided into two groups according to mitotic index and necrosis (grade IIa and IIb) and there was a significant difference between them regarding prognosis (p=0.013 for progression free survival, p=0.003 for overall survival). There was a significant relationship between bcl-2 negative plus focally weak positive cases (9 cases) and focally strong cases (21 cases) and diffuse strong cases (35 cases) (p=0.042 and p=0.016 respectively). There was a significant relation between c-myc negative cases (25 cases) and nuclear positive cases (17 cases) regarding overall survival (p=0.043) and between c-myc negative cases and cytoplasmic positive cases (23 cases) regarding progression free survival (p=0.05). The relation between survivin and prognosis was not significant.

Conclusion: Tumor grade was the most significant prognostic parameter in this study. The grade IIa group (with less than 10 mitoses in 10 HPF, without necrosis) had a better prognosis than both the grade IIb and III groups. The grade IIb group was closer to grade III regarding the prognosis. Bcl-2 and c-myc (nuclear and/or cytoplasmic) immunohistochemical positivity had prognostic value but this finding has to be confirmed by large series.

Keywords : Soft tissue neoplasm, Prognosis, Immunohistochemistry, Bcl-2, Myc