Turkish Journal of Pathology

Türk Patoloji Dergisi

Turkish Journal of Pathology

Turkish Journal of Pathology

2015, Vol 31, Num, 3     (Pages: 219-222)

Primary Gastric Invasive Micropapillary Carcinoma: A Case Report

Enver VARDAR 1, Bengü GÜNAY YARDIM 2, Rukiye VARDAR 3, Mustafa ÖLMEZ 4

1 Department of Pathology, Bozyaka İzmir Training and Research Hospital, İZMİR, TURKEY
2 Manisa State Hospital, İZMİR, TURKEY
3 Ege University Faculty of Medicine, Department of Gastroenterology, İZMİR, TURKEY
4 İzmir Tepecik Training and Research Hospital, Department of General Surgery, İZMİR, TURKEY

DOI: 10.5146/tjpath.2014.01246
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Invasive micropapillary carcinoma is a recently identified neoplasm. A 77-year-old-female was admitted to the hospital due to progressive loss of weight and nausea. Endoscopic biopsy of the antral/prepyloric located mass was diagnosed as moderately differentiated adenocarcinoma. Subtotal gastrectomy and regional lymph node resection were performed. The tumor was composed of moderately differentiated cells arranged in micropapillary structures with only a few poorly formed glandular foci in lamina propria. Immunohistochemically, neoplastic cells of micropapillary and focal conventional adenocarcinoma areas were diffusely positive for pancytokeratin, cytokeratin 7 and epithelial membrane antigen. In micropapillary areas, membranous and peripheral cytoplasmic positivity with epithelial membrane antigen in outside of the cell clusters called “inside-out polarity” pattern that is characteristic for invasive micropapillary carcinoma were seen. Invasive micropapillary carcinoma is very rare in the stomach in the English literature.

Keywords : Stomach neoplasms, Gastrointestinal neoplasms, Papillary carcinoma