Turkish Journal of Pathology

Türk Patoloji Dergisi

Turkish Journal of Pathology

Turkish Journal of Pathology

2015, Vol 31, Num, 0     (Pages: 181-188)

Application of Molecular Pathology in Endocrine Pathology

Ebru Serinsoz LInke 1, Gaye Güler Tezel 2

1 Department of Pathology, Mersin University Faculty of Medicine, MERSİN, Turkey
2 Hacettepe University Faculty of Medicine, Ankara , Turkey

DOI: 10.5146/tjpath.2015.01324
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Rapid growth in knowledge of cell and molecular biology led to the increased usage of molecular techniques in anatomical pathology. This is also due to the advances achieved in the techniques introduced in the last few years which are less laborious as compared to the techniques used at the beginning of the “molecular era”. The initial assays were also very expensive and were not performed except for selected centers. Moreover, the clinicians were not sure how to make use of the accumulating molecular information. That situation has also changed and molecular techniques are being performed in a wide variety of medical settings which also has a reflection on the endocrine system pathology among other organ systems. This review will provide an update of genetic changes observed in different endocrine system pathologies and their diagnostic, therapeutic and prognostic values.

Keywords : BRAF mutation, RET/PTC rearrangement, Thyroid, Adrenal, Genetics