Turkish Journal of Pathology

Türk Patoloji Dergisi

Turkish Journal of Pathology

Turkish Journal of Pathology

2018, Vol 34, Num, 2     (Pages: 165-170)

Evaluation of p53 and Ki67 Expression Profiles in Basal Cell Carcinomas in a Usual and an Unusual Location

Nuran SÜNGÜ 1, Merve Meryem KIRAN 1, Hayriye TATLI DOĞAN 1, Aydan KILIÇARSLAN 1, Emre KARAKÖK 1, Mesut AKYOL 2

1 Department of Pathology, Ankara Yıldırım Beyazit University, Ankara Ataturk Research and Training Hospital, ANKARA, TURKEY
2 Department of Biostatistics, Ankara Yıldırım Beyazit University, Ankara Ataturk Research and Training Hospital, ANKARA, TURKEY

DOI: 10.5146/tjpath.2018.01424
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Objective: Owing to their importance in cell proliferation in cutaneous malignancies, we aimed to immunohistochemically compare the expression profiles of p53 and Ki67 in basal cell carcinoma (BCC) cases in both a usual and an unusual locations in this study.

Material and Method: In this study we included 12 in an unusual location of BCC cases and 21 BCC cases in a usual location. Immunohistochemical expression of p53 and Ki67 antibodies were studied in 33 paraffin-embedded tissue specimens of basal cell carcinoma. We compared the p53 and Ki67 staining scores with clinicopathologic features.

Results: The tumor size was found to be greater in BCC cases in an unusual location than those in a usual location. The relationship between age and tumor size was also evaluated in both groups and it was found that tumor size increased with age. A comparative study between the two groups showed no difference p53 and Ki67 expression percentages. There was a linear correlation between the Ki67 and p53 marker staining rates (ρ=0.420; p=0.015). In the samples taken from cases in a usual region, there was a linear and moderate relationship between the markers (ρ=0.513; p=0.017). Median tumor diameter results were similar to the marker staining score (p>0.05).

Conclusion: This is the first study comparing the expression profiles of p53 and Ki67 of BCC cases in an unusual and a usual location. No significant difference was found concerning Ki67 and p53 expression levels between the two groups.

Keywords : Basal cell carcinoma, p53, Ki67, Location