Turkish Journal of Pathology

Türk Patoloji Dergisi

Turkish Journal of Pathology

Turkish Journal of Pathology

2020, Vol 36, Num, 3     (Pages: 251-255)

Uterine Leiomyoma with Massive Lymphoid Infiltrate in a Patient with History of Assisted In-Vitro Fertilization

Monia DI PRETE 1, Matteo COLLAMARINI 2, Claudio COLLAMARINI 2, Francesco SESTI 2, Alessandro MAURIELLO 1, Giampiero PALMIERI 1

1 Department of Anatomic Pathology,University of Rome Tor Vergata, ROME, ITALY
2 Department of Gynaecology and Obstetrics, University of Rome Tor Vergata, ROME, ITALY

DOI: 10.5146/tjpath.2019.01476
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Uterine leiomyomas are the most common benign tumors of the gynecological tract. Massive lymphocytic infiltration has been reported rarely in uterine leiomyomas and it has been described as a pathogenetic correlation with gonadotropin-releasing hormone agonists. Uterine leiomyomas with massive lymphoid infiltration have to be differentiated from non-Hodgkin lymphomas. We report a case of a woman without a history of gonadotropin-releasing hormone agonist treatment, who presented with a uterine leiomyoma that increased in size after the procedure of assisted in-vitro fertilization, and associated with massive nodular lymphoid infiltrate simulating, morphologically, a non-Hodgkin lymphoma. Uterine leiomyoma with massive lymphocytic infiltration is a very rare entity, probably of reactive significance, which has to be differentiated from diseases that need a systemic therapeutic approach.

Keywords : Leiomyoma, In-vitro fertilization, Uterine, Lymphoma