Turkish Journal of Pathology

Türk Patoloji Dergisi

Turkish Journal of Pathology

Turkish Journal of Pathology

2021, Vol 37, Num, 3     (Pages: 266-272)

Clinicopathologic and Molecular Analysis of Inflammatory Pseudotumor-Like Follicular/Fibroblastic Dendritic Cell Sarcoma: A Case Report and Review of Literature

Bryan MORALES-VARGAS 1, Kristin DEEB 1, Deniz PEKER 1

1 Department of Pathology and Laboratory Medicine, Emory University School of Medicine, GEORGIA, USA

DOI: 10.5146/tjpath.2021.01523
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Inflammatory pseudotumor-like follicular/fibroblastic dendritic cell (FDC/FRC) sarcoma is an extremely rare neoplasm of the spleen associated with EBV and characterized by spindle cell morphology, dense mixed chronic inflammatory background, and a broad immunophenotypic profile often causing a diagnostic challenge for pathologists. The molecular features of FDC/FRC sarcoma are largely unknown due to a lack of comprehensive data. Here we present the results of next-generation sequencing and Single Nucleotide Polymorphism Copy Number array analysis in a case of FDC/FRC and review the literature.

Keywords : Inflammatory pseudotumor-like follicular/fibroblastic dendritic cell sarcoma, Splenic tumor, BCOR1L1, JAK2