Turkish Journal of Pathology

Türk Patoloji Dergisi

Turkish Journal of Pathology

Turkish Journal of Pathology

2022, Vol 38, Num, 1     (Pages: 060-065)

Eosinophilic Solid and Cystic Renal Cell Carcinoma: From Unclassified to Classified, A Case Report

Rashim SHARMA 1, Balamurugan THIRUNAVUKKARASU 1, Poonam ELHENCE 1, Mahaveer Singh RODHA 2, Binit SUREKA 3

1 Departments of Pathology and Lab Medicine, All India Institute of Medical Sciences, RAJASTHAN, INDIA
2 Departments of Trauma and Emergency, All India Institute of Medical Sciences, RAJASTHAN, INDIA
3 Departments of Diagnostic and Interventional Radiology, All India Institute of Medical Sciences, RAJASTHAN, INDIA

DOI: 10.5146/tjpath.2021.01531
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Eosinophilic solid and cystic renal cell carcinoma (ESC RCC) is a novel tumour with unique morphological and immunohistochemical features. It is a recently described entity after the 2016 World Health Organization Classification of Tumours of the Urinary System and Male Genital Organs and is characterised by a solid cystic tumour composed of polygonal cells with voluminous eosinophilic cytoplasm and CK20 positivity. This tumour has uncertain malignant potential and also has an association with tuberous sclerosis complex (TSC). Sarcomatoid differentiation has not been reported in ESC RCC till now. ESC RCC poses a diagnostic challenge as many eosinophilic/oncocytic renal tumours are included in the differentials. We present a case of ESC RCC with sarcomatoid differentiation in an elderly female without any clinical features of TSC and discuss the differential diagnosis of oncocytic renal tumours.

Keywords : Eosinophilic solid and cystic renal cell carcinoma, Unclassified renal cell carcinoma, Emerging entity, Oncocytic renal tumour