Turkish Journal of Pathology

Türk Patoloji Dergisi

Turkish Journal of Pathology

Turkish Journal of Pathology

2022, Vol 38, Num, 3     (Pages: 292-296)

Placental Chorangiocarcinoma: Case Report with Literature Review of a Rare Entity

Nishant SAGAR 1, Parul TANWAR 1, Nita KHURANA 1, Poonam KASHYAP 2

1 Department of Pathology, Maulana Azad Medical College, NEW DELHI, INDIA
2 Department of Obstetrics and Gynaecology, Maulana Azad Medical College, NEW DELHI, INDIA

DOI: 10.5146/tjpath.2021.01548
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Chorangiocarcinoma is an extremely rare tumor seen in the placenta, with only six cases reported in the literature so far. Its morphological characteristics, criteria for diagnosis, and the pathophysiology remain controversial to date. Although it was predominantly considered a benign entity, a solitary case of distant metastasis has been reported in the literature.

We present a case of this unusual tumor in the preterm placenta of a 29-year-old female. Grossly seen as a grey white nodule, microscopic examination revealed nests of atypical trophoblastic proliferation surrounded by vascularized stroma. No evidence of basement membrane invasion was noted. On immunohistochemistry, the trophoblastic component expressed pancytokeratin, Beta HCG, and Placental Alkaline Phosphatase with high Ki-67 labelling index.

The present case highlights this exceedingly rare entity with emphasis on its morpho-immunohistochemical features along with a review of literature.

Keywords : Chorangiocarcinoma, Chorangioma, Trophoblastic proliferation, Placenta