Turkish Journal of Pathology

Türk Patoloji Dergisi

Turkish Journal of Pathology

Turkish Journal of Pathology

2023, Vol 39, Num, 1     (Pages: 055-063)

cERBB-2/Her-2 Neu Overexpression and Prognostic Significance in Uterine Carcinosarcoma

Huseyin Salih SEMIZ 1, Emel Ebru PALA 2, Behzat CAN 3, Elif ATAG 4, Hatice GUNGOR 4, Muzaffer SANCI 3

1 Department of Medical Oncology, Dokuz Eylül University Institute of Oncology, IZMIR, TURKEY
2 Department of Pathology, Health Science University, Tepecik Education and Research Hospital, IZMIR, TURKEY
3 Department of Gynecological Oncology, Health Science University, Tepecik Education and Research Hospital, IZMIR, TURKEY
4 Department of Medical Oncology, Health Science University, Istanbul Haydarpaşa Numune Education and Research Hospital, ISTANBUL, TURKEY

DOI: 10.5146/tjpath.2022.01588
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Objective: There is not enough data in the literature regarding Her-2 overexpression in uterine carcinosarcomas or its association with the prognosis. The aim of this study was to determine the Her-2 overexpression rate in uterine carcinosarcoma and to evaluate its relationship with the prognosis.

Material and Method: Her-2 protein and gene status were evaluated by immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH), respectively, in hysterectomy specimens from 51 patients with uterine carcinosarcoma.

Results: Her-2 protein expression in the epithelial component was negative in 42 patients (score 0 in 33 cases, score (+1) in 9 cases), score (+2) in 7 patients and score (+3) in 2 patients. None of the patients had Her-2 protein expression within the sarcomatous component of the tumors. Her-2 gene was not amplified in epithelial or mesenchymal tumor areas according to the FISH method. There was no difference between the Her-2 overexpression negative and positive groups in terms of disease-free survival (DFS) and overall survival (OS). Her-2 overexpression was significantly higher in tumors of patients diagnosed at 65 years or older (p=0.046).

Conclusion: In our study, no relationship could be shown between Her-2 overexpression and prognosis in uterine carcinosarcoma. More comprehensive studies are needed to illustrate the relationship between Her-2 overexpression and carcinosarcoma prognosis.

Keywords : Carcinosarcoma, Her-2/neu, Prognosis, Uterine cancer