Turkish Journal of Pathology

Türk Patoloji Dergisi

Turkish Journal of Pathology

Turkish Journal of Pathology

2001, Vol 17, Num, 1-2     (Pages: 025-027)

c-erbB-2 OVEREXPRESSION IN IN SITU AND INVASIVE BREAST CARCINOMA AND ITS RELATIONSHIP TO OTHER PROGNOSTIC PARAMETERS

BARIŞIK Nagehan ÖZDEMİR 1, KANDEMİR Nilüfer ONAK 1, GÜL Aylin EGE 1, ŞENSU Sibel 1, YAVUZER Dilek 1, KARADAYI Nimet 1

1 S.B. Dr. Lütfi Kırdar Eğitim ve Araştırma Hastanesi Patoloji Bölümü

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The purpose of this study was to investigate c-erbB-2 oncoprotein expession in female breast carcinoma and to compare it with other prognostic parameters. The expression of c-erbB-2 oncoprotein was studied immunohistochemically in paraffin embedded biopsy specimens of 46 invasive ductal carcinoma with in situ component and was analysed in relation to histological grade, necrosis, lymphocytic infiltration, stromal elastosis and vascular invasion. High grade tumors with invasive or in situ component showed higher c-erbB-2 expression than low grade tumors. The c-erbB-2 protein was also related to the stromal elastosis in invasive areas. A significant association between c-erbB-2 expression and lymphocytic infiltration, necrosis, vascular invasion was not determined. The results suggest that c-erbB-2 expression can be used as a valuable prognostic parameter in predicting the biological behavior of female brest carcinoma.

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