Surgical treatment is essential for early stage non-small cell lung cancer (NSCLC). It is necessary to elucidate high risk patients in lung cancer because even patients operated in early stages admit with recurrences. In order to determine the prognosis besides clinicoptahologic parameters some molecular markers are currently used. The aim of this study is to evaluate the relation between p53, bcl-2 expressions, proliferation activity, basal membrane pattern and clinicopathological findings and prognosis. Histopathological properties of operated 40 patients were evaluated and immunohistochemical studies were done with p53, bcl-2, Ki-67 and collagen type IV. There were 9 adeno Ca, 2 adenosquamous Ca, 3 large cell Ca and 26 squamous cell carcinoma. The was a significant correlation between tumour differentiation, vascular invasion and survival (P=0,03, P=0,03). No relation was found between histopatological parameters and p53, bcl-2, Ki-67 immunoreactivity and basement membrane staining pattern. There was only correlation between Ki-67 immunoreactivity and survival (P=0,02). As a result besides some clinicopathological parameters proliferation activity was also found as a prognostic criterion. Prognostic significance of p53, bcl-2 basal membrane staining pattern are controversial.