Liver biopsies in hepatitis C virus positive end stage renal patients on hemodialysis were compared to that of chronİc hepatitis C patients without renal diseases. Portal inflammation, Lymphoid aggregates/follicles, steatosis, and interface hepatitis were less common and mild in hemodialysis patients (p< 0,05). Bile duct damage was present in 12.5 % and 37.5 % ofthe hemodialysis patients and patients without renal diseases respectively (p> 0.05). There was no difference between hemodialysis patients and patients without renal diseases in respect to fibrosis score. Oil data showed that hepatitis C virus leads to chronic hepatitis with mild activity but with similar risk of progressive liver disease as in chronic hepatitis C patients without renal diseases.