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DOI: 10.5146/tjpath.2021.01531
Eosinophilic Solid and Cystic Renal Cell Carcinoma: From Unclassified to Classified, A Case Report
Rashim SHARMA1, Balamurugan THIRUNAVUKKARASU1, Poonam ELHENCE1, Mahaveer Singh RODHA2, Binit SUREKA3
1Departments of Pathology and Lab Medicine, All India Institute of Medical Sciences, RAJASTHAN, INDIA
2Departments of Trauma and Emergency, All India Institute of Medical Sciences, RAJASTHAN, INDIA
3Departments of Diagnostic and Interventional Radiology, All India Institute of Medical Sciences, RAJASTHAN, INDIA
Keywords: Eosinophilic solid and cystic renal cell carcinoma, Unclassified renal cell carcinoma, Emerging entity, Oncocytic renal tumour

Eosinophilic solid and cystic renal cell carcinoma (ESC RCC) is a novel tumour with unique morphological and immunohistochemical features. It is a recently described entity after the 2016 World Health Organization Classification of Tumours of the Urinary System and Male Genital Organs and is characterised by a solid cystic tumour composed of polygonal cells with voluminous eosinophilic cytoplasm and CK20 positivity. This tumour has uncertain malignant potential and also has an association with tuberous sclerosis complex (TSC). Sarcomatoid differentiation has not been reported in ESC RCC till now. ESC RCC poses a diagnostic challenge as many eosinophilic/oncocytic renal tumours are included in the differentials. We present a case of ESC RCC with sarcomatoid differentiation in an elderly female without any clinical features of TSC and discuss the differential diagnosis of oncocytic renal tumours.

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