SCImago Journal & Country Rank
This journal is a member of, and subscribes to the principles of, the Committee on Publication Ethics (COPE)
[ PDF ] [ Similar Articles ]
DOI: 10.5146/tjpath.2022.01589
Neuroendocrine Tumor of the Fallopian Tube and Serous Adenocarcinoma of the Ovary: Multicentric Primary Tumors
Nataliia HYRIAVENKO1, Mykola LУNDІN1, Vladyslav SIKORA1, Ruslana CHYZHMA1, Yulia LУNDІNA2, Kateryna SIKORA1, Wireko Andrew AWUAH3, Anatolii ROMANIUK1
1Department of Pathology, Sumy State University, SUMY, UKRAINE
2Department of Morphology, Sumy State University, SUMY, UKRAINE
3Department of Student, Sumy State University, SUMY, UKRAINE
Keywords: Neuroendocrine tumor, Fallopian tube, Serous adenocarcinoma, Ovary, Multicentric primary tumors

Neuroendocrine tumors (NETs) comprise a large group of tumors that are most often localized in the gastrointestinal tract and lungs. They are rarely found in the organs of the female reproductive tract; such NETs are primarily localized in the ovaries. We present a case of multicentric primary low-grade NET of the fallopian tube and high-grade ovarian serous adenocarcinoma. In both tumor regions, the histotypes of neoplasms were determined by morphological and immunohistochemical investigations. The NET of the fallopian tube was diffusely positive for chromogranin A and CD56, but wild type for p53 and negative for CK7, CK20, and ER; Ki-67 expression was observed in 3% of the neoplastic cells. The ovarian serous adenocarcinoma was positive for CK7 and ER, mutant for p53, but negative for chromogranin A, CK20, and CD56; Ki-67 expression was observed in 45% of the tumor cells. These results support the possibility that NET can occur in the female reproductive tract and coexist with other malignant tumors.

[ PDF ] [ Similar Articles ]