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2005, Volume 21, Number 1-2, Page(s) 024-026     
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İstanbul Üniversitesi, Cerrahpaşa Tıp Fakültesi, Patoloji Anabilim Dalı, İstanbul
Keywords: Glandular neurofibroma, immunohistochemistry, glands

Glandular differentiation is the rarest form of heterologous differentiation in peripheral nerve sheath tumors. Glandular neurofibroma is a lesion characterized by proliferation of spindle cells admixed with mucus secreting glands. In the literature benign glandular elements’ existence were reported in Schwannoma and malignant peripheral nerve sheath tumor whereas glandular neurofibromas were rarely reported. Presented case was a 56 year-old woman with a 10 year history of a nodule on the left lower leg and local excision of this nodule was performed. On macroscopic examination, the cut surface of the nodule revealed multiple cystic spaces, some of which reaching 1 mm in size. On microscopic examination, the lesion was composed of irregular bundles of spindle cells that most of which parallel to each other. The lesion was moderately cellular and has an infiltrative border with the surrounding adipose tissue. The glands were lined by cuboidal to columnar cells. Amorphous eosinophilic material was observed in some of the glandular lumens. The spindle cells were positive with S-100, the glandular epithelium were positive with cytokeratin. The epithelial cells contained PAS and d-PAS positive neutral mucin while the glandular epithelium and luminal secret had mucicarmen positive acidic mucin. Mast cells were demonstrated with toluidine blue and with all this features the case was found to be suited with a glandular neurofibroma.

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