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2009, Volume 25, Number 3, Page(s) 118-121     
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DOI: 10.5146/tjpath.2009.01165
Micronodular Thymoma with Lymphoid Stroma: Case Report
Ebru ÇAKIR1, Funda DEMİRAĞ1, Göktürk FINDIK2, Sadi KAYA2
Atatürk Göğüs Hastalıkları ve Göğüs Cerrahisi Eğitim ve Araştırma Hastanesi, 1Patoloji ve 2Göğüs Cerrahisi Bölümleri, ANKARA, TÜRKİYE
Departments of 1Pathology and 2Chest Surgery, M.H. Atatürk Chest Diseases and Chest Surgery Education and Research Hospital, ANKARA, TURKEY
Keywords: Micronodular thymoma, Histology, Immunohistochemistry

A 77-year-old female with a history of hypertension was admitted to our hospital for cough lasting for 1 year. Computed tomography showed a 5x4x3 cm nodular anterior mediastinal mass. A complete surgical resection of the tumor was performed by median sternotomy. Macroscopically the mass 5x4x3 cm was surrounded by a thin capsule. Microscopically a tumoral tissue characterized by a proliferation of multiple epithelial nodules seperated by an abundt lymphoid tissue was seen. The surrounding lymphoid tissue contained a dense proliferation of small lymphocytes forming lymphoid follicles with prominent germinal centers. Immunohistochemically, the epithelial cells were positive for pancytokeratin and CK5/6, lymphoid follicles were positive for CD20 and few scattered lymphoid cells in and around the nodules were positive for CD 3 and CD5. Histopathologic diagnosis was micronodular thymoma.

It is important to differentiate these tumors from other types of thymomas because of their association with low grade lymphomas. A rare case of micronodular thymoma was presented and discussed with the literature.

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