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2010, Volume 26, Number 3, Page(s) 238-242
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DOI: 10.5146/tjpath.2010.01030 |
The Role of CD56, HBME-1, and p63 in Follicular Neoplasms of the Thyroid |
Hülya ETEM1, Selver ÖZEKİNCİ2, Bülent MIZRAK2, Senem ŞENTÜRK3 |
1Department of Pathology, Kızıltepe State Hospital, MARDİN, TURKEY
2Department of Pathology, Dicle University, Faculty of Medicine, DİYARBAKIR, TURKEY
3Department of Radiology, Dicle University, Faculty of Medicine, DİYARBAKIR, TURKEY |
Keywords:
Thyroid cancer, Papillary thyroid carcinoma, Follicular Neoplasms |
Objective: Carcinomas originating from thyroid follicular cells are
the commonest of all endocrine system malignancies. In this study we
evaluated the importance of the expressions of CD 56, HBME-1 and
p63 in the differential diagnosis of the follicular variant of papillary
carcinoma from other follicular neoplasms.
Material and Method: We re-evaluated 80 cases of thyroid neoplasms,
comprising 40 cases of follicular variant of papillary thyroid carcinoma
and 40 cases of follicular neoplasm, diagnosed at Dicle University
Medical School, Department of Pathology between 2005 and 2008.
All neoplasms were stained with CD 56, HBME-1 and p 63 compared
to each other. Statistical analysis was with Student's t test and the Yates
corrected chi-square test.
Result: There was no statistically significant difference in the expression
of CD 56 between follicular neoplasms and papillary carcinomas, but
HBME-1 and p63 expressions were statistically significantly different
between these neoplasms (p=0.005, p=0.0001).
Conclusion: The use of HBME-1 and p63 may be helpful in
differentiating papillary carcinoma, particularly follicular variant,
from follicular neoplasms.
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