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2006, Volume 22, Number 1, Page(s) 057-060     
[ Abstract (Turkish) ] [ Full Text ] [ PDF ] [ Similar Articles ]
Cytologic diagnosis of toxoplasma gondii lymphadenitis: A case report
Aptullah HAHOLU1, Şükrü YILDIRIM1, Özgür KORU2, Nurittin ARDIÇ3, Hüseyin BALOĞLU1
1GATA Haydarpaşa Eğitim Hastanesi Patoloji Servis Şefliği, İstanbul
2GATA Askeri Tıp Fakültesi Mikrobiyoloji ve Klinik Mikrobiyoloji Anabilim Dalı, Parazitoloji Bilim Dalı, İstanbul
3GATA Haydarpaşa Eğitim Hastanesi Mikrobiyoloji ve Klinik Mikrobiyoloji Servis Şefliği, İstanbul
Keywords: Toxoplasma lymphadenitis, cytology

The aim of this study is to present cytologic features of fine needle aspiration (FNA) of lymph node suggesting toxoplasmosis with demonstration of histiocytes containing tissue bradyzoites. A 3-year-old female presented with a mobile, tender, 3 cm diameter swelling in submandibular region. FNA smears showed features of reactive lymphoid hyperplasia with polymorphic cells including groups of histiyocytes. Many epitelioid histiocytes containing intracytoplasmic particules suggesting toxoplasma bradyzoites were also seen in a Papanicolaou -stained smear. Although serologic tests did not reveal a high titer of IgG and IgM-specific antibodies to Toxoplasma gondii, the diagnosis of Toxoplasma lymphadenitis was confirmed by demonstrating the sequence specific for toxoplasma genom of the DNA in the material scraped from the stained slides with PCR technique. FNA cytology is a valuable diagnostic tool for toxoplasma lymphadenitis, which especially demonstrates epithelioid histiocytes containing tissue bradyzoites. Although serology may not be supportive, PCR study may confirm the diagnosis.

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