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2011, Volume 27, Number 1, Page(s) 012-016
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DOI: 10.5146/tjpath.2010.01040 |
Cytopathologic Diagnosis in Pleural Effusion and Cyto-Histopathologic Correlation |
Adile Ferda DAĞLI, Şirin KÜÇÜK, Müge SEZER, Özlem ÜÇER |
Department of Pathology, Fırat University, Faculty of Medicine, ELAZIĞ, TURKEY |
Keywords:
Pleural effusion, Cytopathology, Histopathology |
Objective: Cytological examination of pleural fluids is a fast, efficient
and non-invasive diagnostic method. Identification of malignant
effusions bears critical importance in treatment and prognosis. The
aim of this study was to investigate the distribution of cytopathologic
diagnoses in pleural effusions and the cyto-histopathologic correlation
rates.
Material and Method: A total of 298 pleural fluid cases diagnosed
from 2008 to 2009 in our laboratory were retrospectively identified
as the study group. Evaluation results were classified in 5 groups
as inconclusive, benign, atypical, suspicious and malignant, and
compared with the biopsy results.
Results: Of the total 298 pleural fluid cases, 114 (38.3%) were females
and 184 (61.7%) were males. The age range was between 15 and 89
with a mean value of 58.4±17.8. Of the cases, 3 (1%) were diagnosed
as inadequate, 246 (82.6%) benign, 8 atypical, 10 suspicious, and
31 malignant by cytology. Among the cases who were diagnosed
as malignant, 24 (8.1%) were reported as metastatic carcinoma and
7 (2.3%) as malignant mesothelioma. Of the 8 cases reported as
atypical, biopsy results of 2 showed malignant mesothelioma, and of
the 10 cases reported as suspicious, 1 case whose biopsy result was
obtained was diagnosed as epidermoid carcinoma metastasis.
Conclusion: Cytological examination is the most valuable diagnostic
method for pleural effusions which may have various etiological
causes. The most common cause of pleural effusions in our region
is metastatic carcinomas including those from the lung, breast and
ovarian tumors, followed by malignant mesothelioma.
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