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2011, Volume 27, Number 2, Page(s) 110-115
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DOI: 10.5146/tjpath.2011.01058 |
CD138 Expression in Renal Tumors and Its Usage in the Differential Diagnosis |
Ayhan ÖZCAN1, Ertuğrul ÇELİK1, Yıldırım KARSLIOĞLU1, Şeref BASAL2 |
1Department of Pathology, Gülhane Military Medical Academy, School of Medicine, ANKARA, TURKEY
2Department of Urology, Gülhane Military Medical Academy, School of Medicine, ANKARA, TURKEY |
Keywords:
Renal neoplasms, Syndecans, Immunohistochemistry, Differential diagnosis |
Objective: The differential diagnosis of kidney tumors, especially those
with eosinophilic cytoplasms, can be problematic due to overlapping
morphologic features. CD138 is primarily a plasma cell marker but
is known to be expressed in the proximal renal tubular epithelium
as well. This study aims to investigate the possible contribution of
CD138 expression in the differential diagnosis of kidney tumors with
eosinophilic cytoplasm.
Material and Method: The case series consisted of 15 chromophobe
(ChRCC), 5 eosinophilic variant (EoRCC), 10 clear cell (CCRCC)
and 9 papillary (PRCC) renal cell carcinomas, and 13 oncocytomas.
Sections obtained from representative paraffin blocks were stained
against CD138 antibody.
Results: All CCRCC and PRCC showed membranous CD138
expression. In some of the other eosinophilic renal tumors,
cytoplasmic CD138 labeling in varying degrees was detected. In
CCRCC cases, CD138 expression was especially observed in low
grade areas and areas showing cystic and pseudopapillary growth
patterns. A similar pattern of cytoplasmic staining was seen in 3 of
the EoRCC and the most of the PRCC cases (6/9).
Conclusion: Our findings suggest that CD138 may contribute to the
differential diagnosis of renal tumors because of the membranous
staining pattern in CCRCC and EoRCC cases and the cytoplasmic
staining in CHRCC and oncocytoma cases. Its contributory role may
be improved by combined usage with markers like Cytokeratin 7 and
RCC marker.
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