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2011, Volume 27, Number 2, Page(s) 164-168     
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DOI: 10.5146/tjpath.2011.01068
Sarcomatoid Chromophobe Renal Cell Carcinoma with Osteosarcoma-Like Differentiation which Presented as a Retroperitoneal Mass: A Case Report
Ayşegül SARI1, Gözde EVCİM1, Murat ERMETE1, Serhat GÜR2
1Department of Pathology, M.H. İzmir Atatürk Education and Research Hospital, İZMİR, TURKEY
2Department of 1st Surgery, M.H. İzmir Atatürk Education and Research Hospital, İZMİR, TURKEY
Keywords: Sarcomatoid renal cell carcinoma, Chromophobe renal cell carcinoma, Retroperitoneal neoplasms

Sarcomatoid component can occur in all histological subtypes of renal cell carcinoma but most commonly accompanies chromophobe renal cell carcinoma. The majority of the sarcomatoid components consist of malignant fibrous histiocytoma, fibrosarcoma or undifferentiated sarcoma areas. Heterologous differentiation in the form of osteosarcoma or rhabdomyosarcoma is very rarely encountered. We report a very rare case of a chromophobe renal cell carcinoma with osteosarcomatous differentiation that presented as a retroperitoneal mass. Renal cell carcinoma with sarcomatoid change should be always kept in mind when a retroperitoneal mass with sarcomatoid differentiation is encountered.

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