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2015, Volume 31, Number 1, Page(s) 068-071     
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DOI: 0.5146/tjpath.2013.01191
Pleuropulmonary Blastoma: A Case Report
Sümeyye EKMEKCİ1, Anıl AYSAL1, Nur OLGUN2, Mustafa OLGUNER3, Handan ÇAKMAKCI4, Erdener ÖZER1
1Department of Pathology, Dokuz Eylül University, Faculty of Medicine, İZMİR, TURKEY
2Department of Children Health and Disease, Dokuz Eylül University, Faculty of Medicine, İZMİR, TURKEY
3Department of Pediatric Surgery, Dokuz Eylül University, Faculty of Medicine, İZMİR, TURKEY
4Department of Radiology, Dokuz Eylül University, Faculty of Medicine, İZMİR, TURKEY
Keywords: Lung neoplasms, Child, Pleuropulmonary blastoma

Pleuropulmonary blastoma is rare embryonal tumor of infancy and early childhood and it often arises from lung and more rarely from the parietal pleura. We present this entity which has no systematic data associated with its incidence in order to discuss clinical, histopathological, immunohistochemical features and the differential diagnosis. A three-year-old boy presented with fever showed signs of upper respiratory tract infection. Radiological examination revealed a solid mass filling the right hemithorax. The patient underwent core needle biopsy, wedge biopsy and lobectomy. Biopsy and surgical material were examined histopathologically. The tumor was composed of predominantly solid areas consisting blastemal cells with spindle, polygonal and round nuclei in the myxoid stroma. Immunohistochemical staining of the tumor cells were positive with vimentin and desmin. MIB-1 labeling index was above 90%. Histological diagnosis was pleuropulmonary blastoma type 3. The surgically sampled adjacent diafragma was also infiltrated with the tumor. The patient was treated with chemotherapy and showed no signs of recurrence in the follow-up of 9 months. Pleuropulmonary blastoma is a very rare childhood cancer that needs to be kept in mind in the pathological differential diagnosis of thoracic tumors in the children.

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