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2016, Volume 32, Number 2, Page(s) 130-134
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DOI: 10.5146/tjpath.2013.01209 |
Chordoid Meningioma - A Case Report: Clinicopathological Features and Differential Diagnosis of an Uncommon Tumor |
Hatice ÖZER1, Ersin TUNCER1, Gönül SARAY1, Mustafa GÜRELİK2, İbrahim ÖZTOPRAK3, Reyhan EĞİLMEZ1 |
1Cumhuriyet Üniversitesi, Tıp Fakültesi, Patoloji Anabilim Dalı, SİVAS, TÜRKİYE
2Cumhuriyet Üniversitesi, Tıp Fakültesi, Beyin ve Sinir Cerrahisi Anabilim Dalı, SİVAS, TÜRKİYE
3Cumhuriyet Üniversitesi, Tıp Fakültesi, Radyoloji Anabilim Dalı, SİVAS, TÜRKİYE
1Department of Pathology, Cumhuriyet University, Faculty of Medicine, SİVAS, TURKEY
2Department of Neurosurgery, Cumhuriyet University, Faculty of Medicine, SİVAS, TURKEY
3Department of Radiology, Cumhuriyet University, Faculty of Medicine, SİVAS, TURKEYty of Medicine, SİVAS, TURKEY |
Keywords:
Central nervous system neoplasms, Meningioma, Differential diagnosis |
Meningiomas are tumors that originate from the arachnoid cell
and the majority are benign and grade I tumors according to World
Health Organization. Chordoid meningioma is an uncommon
variant of meningioma and corresponds to grade II tumor in the
World Health Organization Classification of Tumors of the Nervous
System 2007 because of its more aggressive behavior and increased
likelihood of recurrence. A 75-year-old female was referred to
the neurosurgery department complaining of headache, syncope,
and seizure. Radiological examination revealed a mass lesion in
the neighbourhood of the frontal lobe that destructed bone and
was associated with peritumoral edema. The patient underwent
surgery. The tumor was totally excised with the dura beneath.
Histopathological examination showed that the tumor was composed
of clusters and cords of small polygonal cells with fine chromatin and
eosinophilic vacuolated cytoplasm embedded in a myxoid matrix,
and also focal whorls of spindle-shaped cells. Two mitoses were seen
in 10 high power fields. Vascular proliferation was observed in some
tumoral areas. Bone invasion was present. Immunohistochemical
analysis of the tumor cells revealed widespread strong membranous
and cytoplasmic expression of epithelial membrane antigen. The Ki67
labeling index was 6-8%. All of these findings were consistent with
a diagnosis of chordoid meningioma, the neoplasm was identified
as grade II based on the World Health Organization Classification,
2007. In this report we present a case of chordoid meningioma
without classical radiological findings of meningioma with areas of
vascular proliferation that mimicked glial tumors at histopathologic
examination.
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