|
2014, Volume 30, Number 1, Page(s) 030-037
|
|
DOI: 10.5146/tjpath.2013.01203 |
Correlation of Survivin and MMP9 Expressions with Prognosis and Clinicopathological Parameters in Surface Epithelial Ovarian Carcinomas |
Fatmagül KUŞKU ÇABUK1, Seyran YİĞİT2, Lütfiye DEMİR3, Fulya ÇAKALAĞAOĞLU2, Oktay TARHAN3 |
1Department of Pathology, İzmir Aliağa State Hospital, İZMİR, TURKEY 2Departments of Pathology, Katip Çelebi University, İzmir Atatürk Education and Research Hospital, İZMİR, TURKEY 3Departments of Oncology, Katip Çelebi University, İzmir Atatürk Education and Research Hospital, İZMİR, TURKEY |
Keywords:
Ovarian neoplasms, MMP-9, Survivin, Prognosis |
Objective: Pathological stage is the most important prognostic factor
in ovarian carcinomas, and many studies have been carried out to
predict prognosis. In our study, we searched the expression of survivin,
which prevents apoptosis and matrix metalloproteinase-9 (MMP-9),
which promotes the metastasis of the tumour by splitting up the basal
membrane in primary epithelial ovarian carcinomas. We aimed to
observe their effects on prognosis by comparing clinicopathological
parameters.
Material and Method: 60 cases diagnosed with epithelial ovarian
carcinoma between 2003 and 2008 and treated and followed up at the
oncology clinic were included in the study. 42 patients were serous, 11
endometrioid, 5 mixed type, 1 was clear cell and 1 was undifferentiated
adenocarcinoma. Survivin and MMP-9 expression was evaluated in
each tumour and assosication with clinicopathological parameters
(age, tumour diameter, localisation, histological type of tumour,
grade, stage, recurrence and metastasis) were searched and also
overall survival and disease free of survival were evaluated.
Results: Survivin was statistically insignificant within the
clinicopathological parameters. The correlation between the tumour
grade and the staining density of MMP-9 in epithelial cells (p=0.028)
and the correlation between disease free of survival and MMP-9
expression in stromal cells (p=0.0326) was significant. When the
stage was compered with clinocopathologic parameters; recurrence
(p=0.005) and death rates (p<0.001) were significantly increased
but overall survival (p=0.0269) was significantly decreased in
advanced-stage patients.
Conclusion: In the present study, the stage was found to be an
important prognostic parameter in surface epithelial ovarian
carcinomas and an association was found between MMP-9 stromal
staining and survival.
|
|
|
|