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2014, Volume 30, Number 2, Page(s) 133-136
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DOI: 10.5146/tjpath.2014.01238 |
Metastatic Squamous-Cell Carcinoma of the Lung Arising in a 12-Year-Old Boy with Juvenile Recurrent Respiratory Papillomatosis of Neonatal Onset |
Sabah BOUDJEMAA1, Nicolas LEBOULANGER1, Linda DAŻNESE1, Patricia DE CREMOUX1, Hubert DUCOU LE POINTE2, Aurore COULOMB1 |
1Department of Pathology, Hopital Armand Trousseau, PARIS, FRANCE
2Department of Radiology, Hopital Armand Trousseau, PARIS, FRANCE |
Keywords:
Human papillomavirus, Squamous cell carcinoma, Recurrent respiratory papillomatosis, Children |
Juvenile recurrent respiratory papillomatosis is the most common
benign neoplastic disease of the larynx in children, characterized by
numerous squamous papillomas caused by Human Papilloma Virus
type 6 and 11. HPV is thought to be acquired at the time of vaginal
delivery from maternal genital condylomas. Juvenile recurrent
respiratory papillomatosis can be protracted by surgical interventions
performed to avoid airway obstruction and extend below the vocal
cords as far as the main stem bronchi. Lung involvement in Juvenile
recurrent respiratory papillomatosis seems to be more prevalent than
non-systematic reviews have reported until now and progression to
cancer occurs in a significant proportion of these cases at a younger
age than previously reported. This would suggest that closer attention
should be paid to these children. We report a case of malignant
transformation in a 12 year-old boy followed-up since the birth for an
invasive juvenile recurrent respiratory papillomatosis with pulmonary
involvement. The presence of HPV 6/11 was demonstrated by PCR
analysis performed on material obtained from a metastatic vertebral
lesion.
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