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2014, Volume 30, Number 2, Page(s) 094-099
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DOI: 10.5146/tjpath.2014.01241 |
Caveolin-1 Expression in Odontogenic Cysts and Ameloblastomas |
Zohreh JAAFARI-ASHKAVANDI, Soheil PARDIS, Maryam ASADZADEH, Azadeh ANDISHEH-TADBIR, Ali DEHGHANI-NAZHVANI |
Department of Oral and Maxillofacial Pathology, School of Dentistry, Shiraz University of Medical Sciences, SHIRAZ, IRAN |
Keywords:
Ameloblastoma, Odontogenic cyst, Caveolin-1, Immunohistochemistry |
Objective: The aim of this study is to evaluate the caveolin-1
expression in a group of odontogenic cysts and tumors.
Material and Method: In this cross-sectional study, the expression
of caveolin-1 was evaluated immunohistochemically in 75 samples
including 18 cases of dentigerous cyst, 18 odontogenic keratocysts,
3 orthokeratinized odontogenic cysts, 2 calcifying odontogenic cysts
and 34 ameloblastomas (solid and unicystic).
Results: Positive immunohistochemical reaction was found in 100%
of odontogenic cysts and this was significantly more than both
unicystic (65%) and solid (55%) ameloblastomas.
Conclusion: The present study showed the expression of caveolin-1
in all odontogenic cysts and more than ameloblastomas. The results
suggested that absence of caveolin-1 might enhance aggressiveness of
odontogenic lesions and could be a useful marker for distinguishing
ameloblastomas from other odontogenic lesions.
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