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2015, Volume 31, Number 3, Page(s) 219-222
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DOI: 10.5146/tjpath.2014.01246 |
Primary Gastric Invasive Micropapillary Carcinoma: A Case Report |
Enver VARDAR1, Bengü GÜNAY YARDIM2, Rukiye VARDAR3, Mustafa ÖLMEZ4 |
1Department of Pathology, Bozyaka İzmir Training and Research Hospital, İZMİR, TURKEY
2Manisa State Hospital, İZMİR, TURKEY
3Ege University Faculty of Medicine, Department of Gastroenterology, İZMİR, TURKEY
4İzmir Tepecik Training and Research Hospital, Department of General Surgery, İZMİR, TURKEY |
Keywords:
Stomach neoplasms, Gastrointestinal neoplasms, Papillary carcinoma |
Invasive micropapillary carcinoma is a recently identified
neoplasm. A 77-year-old-female was admitted to the hospital due
to progressive loss of weight and nausea. Endoscopic biopsy of
the antral/prepyloric located mass was diagnosed as moderately
differentiated adenocarcinoma. Subtotal gastrectomy and regional
lymph node resection were performed. The tumor was composed of
moderately differentiated cells arranged in micropapillary structures
with only a few poorly formed glandular foci in lamina propria.
Immunohistochemically, neoplastic cells of micropapillary and
focal conventional adenocarcinoma areas were diffusely positive
for pancytokeratin, cytokeratin 7 and epithelial membrane antigen.
In micropapillary areas, membranous and peripheral cytoplasmic
positivity with epithelial membrane antigen in outside of the cell
clusters called “inside-out polarity” pattern that is characteristic for
invasive micropapillary carcinoma were seen. Invasive micropapillary
carcinoma is very rare in the stomach in the English literature.
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